Publications

  1. Slaats M, Vos W, Van Holsbeke C, De Backer J, Loterman D, De Backer W, et al. Predicting the effect of treatment in paediatric OSA by clinical examination and functional respiratory imaging. Pediatr Pulmonol. 2017 Mar 1.
  2. Henderson WR, Molgat‐Seon Y, Vos W, Lipson R, Ferreira F, Kirby M, et al. Functional respiratory imaging, regional strain, and expiratory time constants at three levels of positive end expiratory pressure in an ex vivo pig model. Physiological Reports. 2016 Dec 1;4(23):e13059.
  3. Hajian B, de Backer J, Vos W, van Holsbeke C, Ferreira F, Quinn D, et al. Pulmonary vascular effects of pulsed inhaled nitric oxide in COPD patients with pulmonary hypertension. International Journal of Chronic Obstructive Pulmonary Disease. 2016 Jul;Volume 11:1533–41.
  4. Hajian B, De Backer J, Vos W, Aerts J, Cluckers J, De Backer W. Efficacy of inhaled medications in asthma and COPD related to disease severity. Expert Opinion on Drug Delivery. 2016 Jun 13;accepted.
  5. Schepens T, Cammu G, Maes S, Desmedt B, Vos W, Deseure K. Functional respiratory imaging after neostigmine- or sugammadex-enhanced recovery from neuromuscular blockade in the anaesthetised rat: a randomised controlled pilot study. Brazilian Journal of Anesthesiology (English Edition). 2016 Apr 20.
  6. Hajian B, De Backer J, Vos W, Van Holsbeke C, Clukers J, De Backer W. Functional respiratory imaging (FRI) for optimizing therapy development and patient care. Expert Review of Respiratory Medicine. 2016 Feb 1;10(2):193–206.
  7. Vos W, Hajian B, De Backer J, Van Holsbeke C, Vinchurkar S, Claes R, et al. Functional respiratory imaging to assess the interaction between systemic roflumilast and inhaled ICS/LABA/LAMA. International Journal of Chronic Obstructive Pulmonary Disease. 2016 Feb;263.
  8. De Backer J, Van Holsbeke C, Vos W, Vinchurkar S, Dorinsky P, Rebello J, et al. Assessment of lung deposition and analysis of the effect of fluticasone/salmeterol hydrofluoroalkane (HFA) pressurized metered dose inhaler (pMDI) in stable persistent asthma patients using functional respiratory imaging. Expert review of respiratory medicine. 2016;1–7.
  9. Tahir BA, Van Holsbeke C, Ireland RH, Swift AJ, Horn FC, Marshall H, et al. Comparison of CT-based Lobar Ventilation with 3He MR Imaging Ventilation Measurements. Radiology. 2016;278(2):585–92.
  10. Slaats MA, Van Hoorenbeeck K, Van Eyck A, Vos WG, De Backer JW, Boudewyns A, et al. Upper airway imaging in pediatric obstructive sleep apnea syndrome. Sleep Medicine Reviews. 2015 Jun;21:59–71.
  11. Kim M, Bordas R, Vos W, Hartley RA, Brightling CE, Kay D, et al. Dynamic flow characteristics in normal and asthmatic lungs. Int J Numer Method Biomed Eng. 2015 May 30;
  12. Bos AC, Van Holsbeke C, De Backer JW, van Westreenen M, Janssens HM, Vos WG, et al. Patient-Specific Modeling of Regional Antibiotic Concentration Levels in Airways of Patients with Cystic Fibrosis: Are We Dosing High Enough? PLoS ONE. 2015 Mar 3;10(3):e0118454.
  13. Janssens A, Vos W, Holsbeke CV, Schil PV, Oostveen E, Backer JD, et al. Estimation of post-operative forced expiratory volume by functional respiratory imaging. Eur Respir J. 2014 Dec 23;ERJ – 01683–2014.
  14. Tahir BA, Swift AJ, Marshall H, Parra-Robles J, Hatton MQ, Hartley R, et al. A method for quantitative analysis of regional lung ventilation using deformable image registration of CT and hybrid hyperpolarized gas 1H MRI. Physics in Medicine and Biology. 2014 Dec 7;59(23):7267–77.
  15.  De Backer J, Vos W, Vinchurkar S, Van Holsbeke C, Poli G, Claes R, et al. The Effects of Extrafine Beclometasone/Formoterol (BDP/F) on Lung Function, Dyspnea, Hyperinflation, and Airway Geometry in COPD Patients: Novel Insight Using Functional Respiratory Imaging. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2014 Jul 8;28(2):88–99.
  16. De Backer W, Vos W, Van Holsbeke C, Vinchurkar S, Claes R, Hufkens A, et al. The effect of roflumilast in addition to LABA/LAMA/ICS treatment in COPD patients. Eur Respir J. 2014 May 2;erj00117–2014.
  17. Van Holsbeke C, Leemans G, Vos WG, De Backer JW, Vinchurkar SC, Geldof M, et al. Functional respiratory imaging as a tool to personalize respiratory treatment in subjects with unilateral diaphragmatic paralysis. Respiratory Care. 2014;59(9):e127–31.
  18. Burrowes KS, Backer JD, Smallwood R, Sterk PJ, Gut I, Wirix-Speetjens R, et al. Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM). Interface Focus. 2013 Apr 6;3(2):20120057.
  19. Van Holsbeke CS, Verhulst SL, Vos WG, De Backer JW, Vinchurkar SC, Verdonck PR, et al. Change in Upper Airway Geometry Between Upright and Supine Position During Tidal Nasal Breathing. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2013 Mar 19;27(1):51–7.
  20. Vos W, De Backer J, Poli G, De Volder A, Ghys L, Van Holsbeke C, et al. Novel functional imaging of changes in small airways of patients treated with extrafine beclomethasone/formoterol. Respiration. 2013;86(5):393–401.
  21. Vermeulen M, Claessens T, Van Der Smissen B, Van Holsbeke C, De Backer J, Van Ransbeeck P, et al. Manufacturing of patient-specific optically accessible airway models by fused deposition modeling. Rapid Prototyping Journal. 2013;19(5):312–8.
  22. Van Holsbeke C, Vos W, Van Hoorenbeeck K, Boudewyns A, Salgado R, Verdonck P, et al. Functional respiratory imaging as a tool to assess upper airway patency in children with OSA. Sleep Medicine. 2013;14(5):433–9.
  23. De Backer J, Vos W, Van Holsbeke C, Vinchurkar S, Claes R, Parizel P, et al. Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients. International Journal of Chronic Obstructive Pulmonary Disease. 2013;2013(8):569–79.
  24. De Backer LA, Vos W, De Backer J, Van Holsbeke C, Vinchurkar S, De Backer W. The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study. Eur Respir J. 2012 Aug 1;40(2):298–305.
  25. Vinchurkar S, De Backer L, Vos W, Van Holsbeke C, De Backer J, De Backer W. A case series on lung deposition analysis of inhaled medication using functional imaging based computational fluid dynamics in asthmatic patients: effect of upper airway morphology and comparison with in vivo data. Inhalation Toxicology. 2012;24(2):81–8.
  26.  Ides K, Vos W, De Backer L, Vissers D, Claes R, Leemans G, et al. Acute effects of intrapulmonary percussive ventilation in COPD patients assessed by using conventional outcome parameters and a novel computational fluid dynamics technique. Int J Chron Obstruct Pulmon Dis. 2012;7:667–71.
  27. Horemans B, Van Holsbeke C, Vos W, Darchuk L, Novakovic V, Fontan A, et al. Particle deposition in airways of chronic respiratory patients exposed to an urban aerosol. Environmental Science & Technology. 2012;46(21):12162–9.
  28.  Marchandise E, de Wiart CC, Vos WG, Geuzaine C, Remacle J-F. High-quality surface remeshing using harmonic maps—Part II: Surfaces with high genus and of large aspect ratio. Int J Numer Meth Engng. 2011 Jun 17;86(11):1303–21.
  29. Van Holsbeke C, De Backer J, Vos W, Verdonck P, Van Ransbeeck P, Claessens T, et al. Anatomical and functional changes in the upper airways of sleep apnea patients due to mandibular repositioning: a large scale study. Journal of Biomechanics. 2011;44(3):442–9.
  30. De Backer L, Vos W, Salgado R, De Backer J, Devolder A, Verhulst S, et al. Functional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPD. Int J Chron Obstruct Pulmon Dis. 2011;6:637–46.
  31. De Backer L, Vos W, Dieriks B, Daems D, Verhulst S, Vinchurkar S, et al. The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study. Int J Chron Obstruct Pulmon Dis. 2011;6:615–24.
  32. De Backer JW, Vos WG, Vinchurkar SC, Claes R, Drollmann A, Wulfrank D, et al. Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology. 2010 Dec;257(3):854–62.
  33. Vos WG, De Backer WA, Verhulst SL. Correlation between the severity of sleep apnea and upper airway morphology in pediatric and adult patients. Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):26–33.
  34. De Backer JW, Vos WG, Burnell P, Verhulst SL, Salmon P, De Clerck N, et al. Study of the Variability in Upper and Lower Airway Morphology in Sprague–Dawley Rats Using Modern Micro‐CT Scan‐Based Segmentation Techniques. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology. 2009;292(5):720–7.
  35. De Backer JW, Vos WG, Gorlé CD, Germonpré P, Partoens B, Wuyts FL, et al. Flow analyses in the lower airways: patient-specific model and boundary conditions. Med Eng Phys. 2008 Sep;30(7):872–9.
  36. Verhulst SL, De Backer J, Van Gaal L, De Backer W, Desager K. Adenotonsillectomy as First-Line Treatment for Sleep-disordered Breathing in Obese Children. Am J Respir Crit Care Med. 2008 Jun 15;177(12):1399–1399.
  37. De Backer JW, Vos WG, Devolder A, Verhulst SL, Germonpré P, Wuyts FL, et al. Computational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilation. Journal of Biomechanics. 2008;41(1):106–13.
  38. De Backer JW, Vos WG, Verhulst SL, De Backer W. Novel imaging techniques using computer methods for the evaluation of the upper airway in patients with sleep-disordered breathing: a comprehensive review. Sleep medicine reviews. 2008;12(6):437–47.
  39. Vos W, De Backer J, Devolder A, Vanderveken O, Verhulst S, Salgado R, et al. Correlation between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging. Journal of biomechanics. 2007;40(10):2207–13.
  40. De Backer JW, Vanderveken OM, Vos WG, Devolder A, Verhulst SL, Verbraecken JA, et al. Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing. Journal of biomechanics. 2007;40(16):3708–14.

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