White papers
Functional imaging using computer methods to improve respiratory drug development
De Backer JW
free article: download
Journal papers
Change in Upper Airway Geometry between Upright and Supine Position during Tidal Nasal Breathing
Cedric Van Holsbeke, Stijn Verhulst, Wim Vos, Jan De Backer, Samir Vinchurkar, Pascal Verdonck, Johanna van Doorn, Nasser Nadjmi, Wilfried De Backer
Journal of Aerosol Medicine and Pulmonary Drug Delivery 2013 (published ahead of print: doi:10.1089/jamp.2012.1010)
Novel Functional Imaging Of Changes In Small Airways Of Patients Treated With Extrafine Beclomethasone/Formoterol
Wim Vos, Jan De Backer, Gianluigi Poli, Annick Devolder, Liesbet Ghys, Cedric Van Holsbeke, Samir Vinchurkar, Lieve De Backer, Wilfried De Backer
Respiration 2013 (published ahead of print: doi:10.1159/000347120)
Functional respiratory imaging as a tool to assess upper airway patency in children with OSA
Cedric Van Holsbeke, Wim Vos, Kim Van Hoorenbeeck, An Boudewyns, Rodrigo Salgado, Pascal Verdonck, Jose Ramet, Jan De Backer, Wilfried De Backer, Stijn Verhulst
Sleep Medicine 2013;14:433–439
Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM)
Burrowes KS, De Backer J, Smallwood R, Sterk PJ, Gut I, Wirix-Speetjens R, Siddiqui S, Owers-Bradley J, Wild J, Maier D, Brightling C on behalf of the AirPROM Consortium
Interface Focus 2013;3(2):20120057–20120057
Particle deposition in airways of chronic respiratory patients exposed to an urban aerosol
Benjamin Horemans, Cedric Van Holsbeke, Wim Vos, Larysa Darchuk, Velibor Novakovic, Angel Conesa Fontan, Jan De Backer, Rene Ernest Vangrieken, Wilfried De Backer, and Karolien De Wael
Environmental Science & Technology 2012;46(21):12162–12169
The acute effect of budesonide/formoterol in COPD: a multi-slice computed tomography and lung function study
De Backer LA, Vos W, De Backer J, Van Holsbeke C, Vinchurkar S, De Backer W.
European Respiratory Journal 2012;40:298-305.
A case series on lung deposition analysis of inhaled medication using functional imaging based computational fluid dynamics in asthmatic patients: effect of upper airway morphology and comparison with in vivo data
Vinchurkar S, De Backer L, Vos W, Van Holsbeke C, De Backer J, De Backer W.
Inhalation Toxicology 2012 Jan;24(2):81–8.
High-quality surface remeshing using harmonic maps — Part II: Surfaces with high genus and of large aspect ratio
Marchandise E, de Wiart CC, Vos WG, Geuzaine C, Remacle J-F.
International Journal for Numerical Methods in Engineering 2011;86(11):1303–21.
The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study
L De Backer, W Vos, B Dieriks, D Daems, S Verhulst, S Vinchurkar, K Ides, J De Backer, P Germonpre,W De Backer
International Journal of COPD 2011;6:615–624
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Functional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPD
LA De Backer, R Salgado, WG Vos, JW De Backer, A Devolder, SL Verhulst, AS Verstraeten, R Claes, PR Germonpre, WA De Backer
International Journal of COPD 2011;6:637–646
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Anatomical and Functional changes in the Upper Airways of Sleep Apnea Patients due to Mandibular Repositioning: a Large Scale Study
Van Holsbeke C, De Backer J, Vos W, Verdonck P, Van Ransbeeck P, Claessens T, Braem M, Vanderveken O, De Backer W
J Biomech 2011;44:442-449
Validation of computational fluid dynamics (CFD) in CT-based airway models using single photon computed tomography (SPECT).
De BackerJW, Vos WG, Vinchurkar S, Claes R, Drollmann A, Wulfrank D, Parizel P, Germonpre P, De Backer W.
Radiology 2010; 257:854-862
Correlation between the severity of sleep apnea and upper airway morphology in pediatric and adult patients.
Vos WG, De Backer WA, Verhulst SL.
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):26-33. Review.
Study of the variability in upper and lower airway morphology in Sprague-Dawley rats using modern micro-CT scan-based segmentation techniques.
De Backer JW, Vos WG, Burnell P, Verhulst SL, Salmon P, De Clerck N, De Backer W.
Anat Rec (Hoboken). 2009 May;292(5):720-7.
free article: download
Novel imaging techniques using computer methods for the evaluation of the upper airway in patients with sleep-disordered breathing: a comprehensive review.
De Backer JW, Vos WG, Verhulst SL, De Backer W.
Sleep Med Rev. 2008 Dec;12(6):437-47.
Adenotonsillectomy as first-line treatment for sleep-disordered breathing in obese children.
Verhulst SL, De Backer J, Van Gaal L, De Backer W, Desager K.
Am J Respir Crit Care Med. 2008 Jun 15;177(12):1399.
Flow analyses in the lower airways: patient-specific model and boundary conditions.
De Backer JW, Vos WG, Gorlé CD, Germonpré P, Partoens B, Wuyts FL, Parizel PM, De Backer W.
Med Eng Phys. 2008 Sep;30(7):872-9
Computational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilation.
De Backer JW, Vos WG, Devolder A, Verhulst SL, Germonpré P, Wuyts FL, Parizel PM, De Backer W.
J Biomech. 2008;41(1):106-13
Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing.
De Backer JW, Vanderveken OM, Vos WG, Devolder A, Verhulst SL, Verbraecken JA, Parizel PM, Braem MJ, Van de Heyning PH, De Backer WA.
J Biomech. 2007;40(16):3708-14
Correlation between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging.
Vos W, De Backer J, Devolder A, Vanderveken O, Verhulst S, Salgado R, Germonpre P, Partoens B, Wuyts F, Parizel P, De Backer W.
J Biomech. 2007;40(10):2207-13
