White papers
Functional imaging using computer methods to improve respiratory drug development
De Backer JW
free article: download
Journal papers
Double blind, placebo controlled crossover study in COPD patients to assess the acute effect of budesonide/formoterol using multi-slice CT and lung function tests.
De Backer LA, Vos W, De Backer J, Van Holsbeke C, Vinchurkar S, De Backer W.
Eur Respir J. 2011 (in press)
The effects of long-term noninvasive ventilation in hypercapnic COPD patients: a randomized controlled pilot study
L De Backer, W Vos, B Dieriks, D Daems, S Verhulst, S Vinchurkar, K Ides, J De Backer, P Germonpre,W De Backer
International Journal of COPD 2011;6:615–624
open access: download
Functional imaging using computer methods to compare the effect of salbutamol and ipratropium bromide in patient-specific airway models of COPD
LA De Backer, R Salgado, WG Vos, JW De Backer, A Devolder, SL Verhulst, AS Verstraeten, R Claes, PR Germonpre, WA De Backer
International Journal of COPD 2011;6:637–646
open access: download
Anatomical and Funcitonal changes in the Upper Airways of Sleep Apnea Patients due to Mandibular Repositioning: a Large Scale Study
Van Holsbeke C, De Backer J, Vos W, Verdonck P, Van Ransbeeck P, Claessens T, Braem M, Vanderveken O, De Backer W
J Biomech 2011;44:442-449
Validation of computational fluid dynamics (CFD) in CT-based airway models using single photon computed tomography (SPECT).
De BackerJW, Vos WG, Vinchurkar S, Claes R, Drollmann A, Wulfrank D, Parizel P, Germonpre P, De Backer W.
Radiology 2010; 257:854-862
Correlation between the severity of sleep apnea and upper airway morphology in pediatric and adult patients.
Vos WG, De Backer WA, Verhulst SL.
Curr Opin Allergy Clin Immunol. 2010 Feb;10(1):26-33. Review.
Study of the variability in upper and lower airway morphology in Sprague-Dawley rats using modern micro-CT scan-based segmentation techniques.
De Backer JW, Vos WG, Burnell P, Verhulst SL, Salmon P, De Clerck N, De Backer W.
Anat Rec (Hoboken). 2009 May;292(5):720-7.
free article: download
Novel imaging techniques using computer methods for the evaluation of the upper airway in patients with sleep-disordered breathing: a comprehensive review.
De Backer JW, Vos WG, Verhulst SL, De Backer W.
Sleep Med Rev. 2008 Dec;12(6):437-47.
Adenotonsillectomy as first-line treatment for sleep-disordered breathing in obese children.
Verhulst SL, De Backer J, Van Gaal L, De Backer W, Desager K.
Am J Respir Crit Care Med. 2008 Jun 15;177(12):1399.
Flow analyses in the lower airways: patient-specific model and boundary conditions.
De Backer JW, Vos WG, Gorlé CD, Germonpré P, Partoens B, Wuyts FL, Parizel PM, De Backer W.
Med Eng Phys. 2008 Sep;30(7):872-9
Computational fluid dynamics can detect changes in airway resistance in asthmatics after acute bronchodilation.
De Backer JW, Vos WG, Devolder A, Verhulst SL, Germonpré P, Wuyts FL, Parizel PM, De Backer W.
J Biomech. 2008;41(1):106-13
Functional imaging using computational fluid dynamics to predict treatment success of mandibular advancement devices in sleep-disordered breathing.
De Backer JW, Vanderveken OM, Vos WG, Devolder A, Verhulst SL, Verbraecken JA, Parizel PM, Braem MJ, Van de Heyning PH, De Backer WA.
J Biomech. 2007;40(16):3708-14
Correlation between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging.
Vos W, De Backer J, Devolder A, Vanderveken O, Verhulst S, Salgado R, Germonpre P, Partoens B, Wuyts F, Parizel P, De Backer W.
J Biomech. 2007;40(10):2207-13
