Study demonstrates validity and utility of FRI-based V/Q

Exciting new results will be presented at the upcoming European Respiratory Society Conference in Milan from 9-13 September!

The primary function of the respiratory system is the transfer oxygen from the environment into the blood stream of a individual. Consequently in a healthy subject the regional ventilation in the lungs is well matched to the regional perfusion, in other words the air goes where the blood vessels are. Often in diseased lungs a Ventilation/Perfusion (V/Q) mismatch occurs causing oxygen desaturation, fatigue, limited exercise tolerance etc. Today accurately assessing V/Q is challenging as it relies on isotope-based methods which are labour intensive and relatively low in resolution.

In a recent study, FLUIDDA researchers have demonstrated the validity and utility of CT-based V/Q through their proprietary FRI technology. COPD patients who remained hypercapnic after an exacerbation where studied to assess the potential benefit of non-invasive ventilation. The hypercapnia in this cohort was a consequence of V/Q mismatch. FRI-based V/Q (iVQ) consists of assessment of regional ventilation through CT-based lobe expansion and regional perfusion via lobar blood vessel segmentation. Significant correlations (p < 0.001)were found between iVQ and arterial blood gases, exercise tolerance (6MWT) and patient reported outcome parameters (SGRQ).

These findings are of major importance as they facilitate the broader use of V/Q as outcome parameters in clinical trials to phenotype patients and assess treatment efficacy as well as a diagnostic tool in clinical practice.

FLUIDDA’s co-founder and COO, Dr Wim Vos, will present these findings at ERS during an oral presentation on Tuesday September 12th in hall¬†BROWN 1 + 2 (SOUTH) at 16:15.



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