Lung deposition measured by Functional Respiratory Imaging (FRI) of inhaled LAMA via standard jet nebulizer or DPI.
In a recently published study, FRI respiratory imaging was used to determine deposition patterns for revefenacin solution via a PARI LC® Sprint® nebulizer and tiotropium powder via HandiHaler® DPI.
Data for bronchodilator deposition via nebulizers and dry powder inhalers (DPIs) in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD) are limited
Ten patients with COPD, of whom 9 had severe airflow obstruction, were selected from FLUIDDA’s database. Drug deposition in the extrathoracic and intrathoracic regions, including the central and peripheral airways was simulated by FRI. The percentage of delivered dose and central-to-peripheral (C/P) deposition ratio for nebulizer and DPI were evaluated.
The results demonstrated more efficient intrathoracic and peripheral deposition via standard jet nebulizer than tiotropium via HandiHaler, with similar C/P deposition ratio in patients with COPD. Nebulizers proved to be an efficient alternative to DPIs for bronchodilator administration in patients with COPD.
DPI, FRI, LAMA, Nebulizer